Gene expression signatures, pathways and networks in carotid atherosclerosis
Journal of Internal Medicine2015Vol. 279(3), pp. 293–308
Citations Over TimeTop 10% of 2015 papers
Ljubica Perisic, Silvia Aldi, Yuhang Sun, Lasse Folkersen, Anton Razuvaev, Joy Roy, Mariette Lengquist, Susanne Åkesson, Craig E. Wheelock, Lars Mäegdefessel, Anders Gabrielsen, Jacob Odeberg, Göran K. Hansson, Gabrielle Paulsson‐Berne, Ulf Hedin
Abstract
Our findings confirmed a central role for inflammation and proteases in plaque instability, and highlighted haemoglobin metabolism and bone resorption as important pathways. Subgroup analysis suggested prolonged inflammation following the symptoms of plaque instability and calcification as a possible stabilizing mechanism by statins. In addition, transcriptional regulation may play an important role in the determination of plaque phenotype. The results from this study will serve as a basis for further exploration of molecular signatures in carotid atherosclerosis.
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