Effects of Aging on the Human Brain: A Proton and Phosphorus MR Spectroscopy Study at 3T
Journal of Neuroimaging2018Vol. 28(4), pp. 416–421
Citations Over TimeTop 10% of 2018 papers
Birte Schmitz, Xin Wang, Peter B. Barker, Ulrich Pilatus, Paul Bronzlik, Mete Dadak, Kai G. Kahl, Heinrich Lanfermann, Xiaoqi Ding
Abstract
Age-related accumulative metabolic changes in aging human brain correlated with reduced neuronal metabolic activity and density, reflected by decreased NAA, reduced mitochondrial activity by decreased ATP, and reduced membrane synthesis by decreased PME. These changes are associated with age-related decrease of neuronal volume. Global NAA and ATP might be used as surrogate biomarker for monitoring aging in human brain.
Related Papers
- → MR Spectroscopy of the Liver: Principles and Clinical Applications(2009)106 cited
- → Multidimensional MR spectroscopic imaging of prostate cancer in vivo(2013)31 cited
- → Proton MR spectroscopy of craniopharyngiomas(2001)19 cited
- → Influences of Previous Calcium and Phosphorus Intake and Plant Phosphorus on the Requirement of Developing Turkeys for Calcium and Phosphorus(1963)6 cited
- Effect of Calcium to Phosphorus Ratio in Its Utilization in Growing Laboratory Rhesus Monkey(2004)