Quantitative evaluation of brain iron accumulation in different stages of Parkinson's disease
Journal of Neuroimaging2021Vol. 32(2), pp. 363–371
Citations Over TimeTop 10% of 2021 papers
Kailyn R. Li, Josué M. Avecillas-Chasín, Thanh D. Nguyen, Kelly M. Gillen, Alexey Dimov, Eileen Chang, Carly Skudin, Brian H. Kopell, Yi Wang, Alexander Shtilbans
Abstract
Our data suggest iron accumulation occurs early in the disease course and only in the SN and RN of these patients. This is a large cross-sectional study of brain iron deposition in PD patients according to H&Y staging. Prospective studies are warranted to further validate QSM as a method to follow brain iron, which could serve as a disease biomarker and a therapeutic target.
Related Papers
- → Normal Aging in the Basal Ganglia Evaluated by Eigenvalues of Diffusion Tensor Imaging(2009)49 cited
- → MR measurement of the basal ganglia volume in the Tourette syndrome(2014)1 cited
- Visceral responses induced on excitation of caudate nucleus, putamen and globus pallidus.(1976)
- Susceptibility weighted imaging evaluation of brain iron content of gray nucleus in healthy people(2009)
- Correlation study of T_2 signal values of deep brain gray nucleus and estimated iron content at 3.0 Tesla MR(2007)