Intersite brain MRI volumetric biases persist even in a harmonized multisubject study of multiple sclerosis
Journal of Neuroimaging2023Vol. 33(6), pp. 941–952
Citations Over TimeTop 14% of 2023 papers
Kelly Clark, Carly M. O’Donnell, Mark A. Elliott, Shahamat Tauhid, Blake E. Dewey, Renxin Chu, Samar Khalil, Govind Nair, Pascal Sati, Anna DuVal, Nicole Pellegrini, Amit Bar‐Or, Clyde Markowitz, Matthew K. Schindler, Jonathan Zurawski, Peter A. Calabresi, Daniel S. Reich, Rohit Bakshi, Russell T. Shinohara, the NAIMS Cooperative
Abstract
Differences in brain volumetry persisted across MR scanners despite protocol harmonization. These differences were not well explained by variance component modeling; however, statistical innovations for mitigating intersite differences show promise in reducing biases in multicenter studies of MS.
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