Low-volume solubility assessment during high-concentration protein formulation development
Journal of Pharmacy and Pharmacology2016Vol. 70(5), pp. 636–647
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Abstract
The introduced screening procedure is a powerful tool during (early) protein formulation development. It meets several requirements of HCF development and enables reliable prediction of protein solubility based on determination of protein interactions. In addition, rare data about the influence of several common excipients on apparent solubility of therapeutic proteins were shown.
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