A deletion of IDUA exon 10 in a family of Golden Retriever dogs with an attenuated form of mucopolysaccharidosis type I
Journal of Veterinary Internal Medicine2020Vol. 34(5), pp. 1813–1824
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Kiterie M. E. Faller, Alison E. Ridyard, Rodrigo Gutierrez‐Quintana, Angie Rupp, Célia Kun‐Rodrigues, Tatiana Orme, Karen Tylee, Heather J. Church, Rita Guerreiro, José Brás
Abstract
Analysis of the genotype/phenotype correlation in this dog family suggests that dogs with MPS-I could have a less severe phenotype than humans, even in the presence of severe mutations. Treatment with pentosan polyphosphate should be considered in dogs with MPS-I.
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