Sigma‐1 receptor activation‐induced glycolytic ATP production and endothelial barrier enhancement
Microcirculation2020Vol. 27(6), pp. e12620–e12620
Citations Over TimeTop 20% of 2020 papers
Abstract
Activation of σ1 enhances endothelial barrier function and modulates the ratio of glycolytic versus mitochondrial ATP production. These novel findings suggest that endothelial σ1 may prove beneficial as a novel therapeutic target for reducing microvascular hyperpermeability and counteracting mitochondrial dysfunction.
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