Combinatorial model of amyloid β and tau reveals synergy between amyloid deposits and tangle formation
Neuropathology and Applied Neurobiology2021Vol. 48(2), pp. e12779–e12779
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Emily J. Koller, Kristen R. Ibanez, Quan Vo, Karen N. McFarland, Elsa Gonzalez De La Cruz, Lillian Zobel, Tristan Williams, Guilian Xu, Daniel Ryu, Preya Patel, Benoit I. Giasson, Stefan Prokop, Paramita Chakrabarty
Abstract
Our data show that different tau mutations representing specific folding variants of tau synergise with Aβ to different extents, depending on the presence of cerebral deposits.
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