New ghrelin agonist, HM01 alleviates constipation and L‐dopa‐delayed gastric emptying in 6‐hydroxydopamine rat model of Parkinson's disease
Neurogastroenterology & Motility2014Vol. 26(12), pp. 1771–1782
Citations Over TimeTop 13% of 2014 papers
Hiroshi Karasawa, Claudio Pietra, Claudio Giuliano, Silvina García-Rubio, Xinyu Xu, Seiichi Yakabi, Yvette Taché, L. Wang
Abstract
6-OHDA rats display constipation- and adipsia-like features of PD and L-dopa-inhibited GE. The new orally active ghrelin agonist, HM01 crosses the blood-brain barrier and alleviates these alterations suggesting a potential benefit for PD with GI disorders.
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