GABA‐producing Bifidobacterium dentium modulates visceral sensitivity in the intestine
Neurogastroenterology & Motility2016Vol. 29(1)
Citations Over TimeTop 10% of 2016 papers
Karina Pokusaeva, Coreen Johnson, Berkley Luk, Gonzalo Uribe, Yu Fu, Numan Oezguen, Risë K. Matsunami, Mónica Lugo, Angela M. Major, Yuko Mori–Akiyama, Emily B. Hollister, Sara M. Dann, Xuan–Zheng Shi, David Engler, Tor Savidge, James Versalovic
Abstract
The functional significance of microbial-derived GABA was demonstrated by gadB-dependent desensitization of colonic afferents in a murine model of visceral hypersensitivity. Visceral pain modulation represents another potential health benefit attributed to bifidobacteria and other GABA-producing species of the intestinal microbiome. Targeting GABAergic signals along this microbiome-gut-brain axis represents a new approach for the treatment of abdominal pain.
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