New insights into neurogenic cyclic motor activity in the isolated guinea‐pig colon
Neurogastroenterology & Motility2017Vol. 29(10), pp. 1–13
Citations Over TimeTop 10% of 2017 papers
Marcello Costa, Lukasz Wiklendt, Lauren J. Keightley, Simon J. Brookes, Phil G. Dinning, Nick J. Spencer
Abstract
CMCs are a distinctive neurally dependent cyclic motor pattern, that emerge with distension over long lengths of the distal colon. They do not require changes in muscle tension or contractility to entrain the neural activity underlying CMC propagation. CMCs are likely to play an important role interacting with the neuromechanical processes that time the propulsion of multiple natural pellets and may be particularly relevant in conditions of impaction or obstruction, where long segments of colon are simultaneously distended.
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