Inflammatory cell distribution in colon mucosa as a new tool for diagnosis of irritable bowel syndrome: A promising pilot study
Neurogastroenterology & Motility2017Vol. 30(1)
Citations Over TimeTop 11% of 2017 papers
Julien Boyer, Marie‐Christine Saint‐Paul, Bérengère Dadone, Stéphanie Patouraux, M. Vivinus, Delphine Ouvrier, Jean‐François Michiels, T. Piche, Meri K. Tulić
Abstract
Here we report a decreasing gradient of immune cells from the cecum to the rectum of the human colon. Although global cellularity cannot be used to distinguish between IBS and HC, closer analysis of macrophages and mast cells may be useful markers to confirm IBS histologically and to differentiate between IBS-C and IBS-D when clinical presentation alternates between constipation and diarrhoea. This pilot study remains to be confirmed with greater number of patients.
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