The effects of loperamide on excitatory and inhibitory neuromuscular function in the human colon
Neurogastroenterology & Motility2022Vol. 34(11), pp. e14442–e14442
Citations Over TimeTop 23% of 2022 papers
Paul T. Heitmann, Lauren J. Keightley, Lukasz Wiklendt, David A. Wattchow, Simon J. Brookes, Nick J. Spencer, Marcello Costa, Phil G. Dinning
Abstract
Loperamide had no effect on excitatory neuromuscular function in human colonic circular muscle. These findings suggest that loperamide alters colonic function by acting primarily on inhibitory motor neurons, premotor enteric neurons, or via alternative non-opioid receptor pathways.
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