Placebo effect in burning mouth syndrome: a systematic review
Oral Diseases2013Vol. 20(3), pp. e1–6
Citations Over TimeTop 17% of 2013 papers
Abstract
Placebo controls play a critical role in the evaluation of any pharmacotherapy. This review surveys the placebo arm in 12 randomized controlled trials ( RCT s) investigating burning mouth syndrome ( BMS ) and documents a positive placebo response in 6 of them. On average, treatment with placebos produced a response that was 72% as large as the response to active drugs. The lack of homogeneity in the use of placebos adds to the difficulty in comparing results and aggregating data. Future RCT s investigating BMS would benefit from larger sample sizes, adequate follow‐up periods, and use of a standard placebo.
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