Severity and threshold of peanut reactivity during hospital‐based open oral food challenges: An international multicenter survey
Pediatric Allergy and Immunology2018Vol. 29(7), pp. 754–761
Citations Over TimeTop 10% of 2018 papers
Peter D. Arkwright, Jayne MacMahon, Jennifer J. Koplin, Shelly Rajput, Stephanie A. Cross, Róisín Fitzsimons, Neil Davidson, Veena Deshpande, Naveen Rao, Colin Lumsden, David Lacy, Katrina J. Allen, Gillian Vance, James Mwenechanya, Adam Fox, Michel Erlewyn‐Lajeunesse, Hitesh Mistry, Jonathan O’B Hourihane
Abstract
More than a third of the children in this large international cohort tolerated the equivalent of one peanut in an oral challenge. Anaphylaxis, particularly to small amounts of peanut, was more common in older children. Tailored immunotherapy programs might be considered not only for children with low, but also higher reaction thresholds. Whether these programs could prevent heightened sensitivity and anaphylaxis to peanut with age also deserves further study.
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