Phenylephrine eye drops in pediatric patients undergoing ophthalmic surgery: incidence, presentation, and management of complications during general anesthesia
Pediatric Anesthesia2013Vol. 24(4), pp. 400–405
Citations Over TimeTop 11% of 2013 papers
Fabio Sbaraglia, Nadia Mores, Rossella Garra, Giuseppe Giuratrabocchetta, Domenico Lepore, Fernando Molle, Gustavo Savino, Marco Piastra, Silvia Pulitanò, Maria Pia Sammartino
Abstract
Two different patterns of side effects occurred. The first one was a cardiovascular derangement with severe hypertension and heart rate alterations; the other one involved exclusively pulmonary circuit causing early edema. These clinical manifestations, their duration, and treatment responses are all explainable by alfa1-adrenergic action of phenylephrine. This hypothetic pathogenesis has been confirmed also by the usefulness of direct vasodilators (anesthetic agents) and by the negative outcome occurred in the past with the use of beta-blockers.
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