The genome‐wide DNA methylation profiles among neurosurgery patients with and without post‐operative delirium
Psychiatry and Clinical Neurosciences2022Vol. 77(1), pp. 48–55
Citations Over TimeTop 14% of 2022 papers
Takehiko Yamanashi, Kaitlyn J. Crutchley, Nadia E. Wahba, Takaaki Nagao, Pedro S. Marra, Cade C. Akers, Eleanor J. Sullivan, Masaaki Iwata, Matthew A. Howard, Hyunkeun R. Cho, Hiroto Kawasaki, Christopher G. Hughes, Pratik P. Pandharipande, Marco M. Hefti, Gen Shinozaki
Abstract
Our first genome-wide DNAm investigation of POD showed promising signals related to immune response, inflammatory response and other relevant signals considered to be associated with delirium pathophysiology. Our data supports the hypothesis that epigenetics play an important role in the pathophysiological mechanism of delirium and suggest the potential usefulness of an epigenetics-based biomarker of POD.
Related Papers
- → DNA Methylation Clocks and Their Predictive Capacity for Aging Phenotypes and Healthspan(2020)142 cited
- → Epigenome wide comparison of DNA methylation profile between paired umbilical cord blood and neonatal blood on Guthrie cards(2019)20 cited
- → Interrelationships and determinants of aging biomarkers in cord blood(2022)8 cited
- → Blood-based genome-wide DNA methylation correlations across body-fat- and adiposity-related biochemical traits(2023)5 cited
- → Epigenetic clock analysis in methamphetamine dependence(2022)6 cited