Direct Immunofluorescence (DIF) Microscopy of Skin Biopsies From Children: A Retrospective Cohort Study of 986 DIF Studies
Pediatric Dermatology2025Vol. 42(4), pp. 767–772
Clint Christian T. Garbanzos, Jorge A. Rios‐Duarte, Heather D Hardway, Austin Todd, Dawn Marie R. Davis, Julia S. Lehman
Abstract
The most frequent DIF pattern in children was that of IgA-predominant vasculitis. Pediatric DIF positivity rates closely mirrored those of adults, supporting similar biopsy thresholds. DIF results differed from the pretest impression in a substantial percentage, supporting the value of DIF in select situations in the pediatric population. After controlling for IgA vasculitis, biopsy site was not associated with DIF positivity.
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