Protein transport in growing and steady‐state cilia

Citations Over TimeTop 10% of 2017 papers

Abstract

Cilia and eukaryotic flagella are threadlike cell extensions with motile and sensory functions. Their assembly requires intraflagellar transport (IFT), a bidirectional motor-driven transport of protein carriers along the axonemal microtubules. IFT moves ample amounts of structural proteins including tubulin into growing cilia likely explaining its critical role for assembly. IFT continues in non-growing cilia contributing to a variety of processes ranging from axonemal maintenance and the export of non-ciliary proteins to cell locomotion and ciliary signaling. Here, we discuss recent data on cues regulating the type, amount and timing of cargo transported by IFT. A regulation of IFT-cargo interactions is critical to establish, maintain and adjust ciliary length, protein composition and function.

Related Papers

• → A motility in the eukaryotic flagellum unrelated to flagellar beating.(1993)1,002 cited
• → Intraflagellar Transport and Functional Analysis of Genes Required for Flagellum Formation in Trypanosomes(2007)190 cited
• → Intraflagellar transport is required for the maintenance of the trypanosome flagellum composition but not its length(2016)53 cited
• → IFT25 is required for the construction of the trypanosome flagellum(2018)1 cited
• → The role of G proteins in the control of intraflagellar transport(2012)