Comprehensive genotyping for 18 blood group systems using a multiplex ligation‐dependent probe amplification assay shows a high degree of accuracy
Transfusion2013Vol. 53(11pt2), pp. 2899–2909
Citations Over TimeTop 10% of 2013 papers
Lonneke Haer‐Wigman, Yanli Ji, Martin Lodén, Masja de Haas, C. Ellen van der Schoot, Barbera Veldhuisen
Abstract
The blood-MLPA reliably predicts the presence or absence of blood group antigens, including almost all clinically relevant blood group antigens, except ABO, in patients and donors. Furthermore, it is the first assay that determines copy numbers of blood group alleles in the same test. It even provides more detailed and accurate information than serologic typing, because most variant alleles are immediately recognized. Since only standard laboratory equipment is needed, this assay finally offers the possibility to comprehensively type recipients and makes extensive matching for selected patients groups more feasible.
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