Spherocytic shift of red blood cells during storage provides a quantitative whole cell–based marker of the storage lesion
Transfusion2017Vol. 57(4), pp. 1007–1018
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Camille Roussel, Michaël Dussiot, Mickaël Marin, Alexandre Morel, Papa Alioune Ndour, Julien Duez, Caroline Le Van Kim, Olivier Hermine, Yves Colin, Pierre Buffet, Pascal Amireault
Abstract
The reduction in surface area of small RBCs is expected to induce their retention by the spleen. We propose that small RBCs generated by MP-induced membrane loss are preferentially cleared from the circulation shortly after transfusion of long-stored blood. Their operator-independent quantification using imaging flow cytometry may provide a marker of storage lesion potentially predictive of transfusion yield.
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