Red blood cell metabolic responses to refrigerated storage, rejuvenation, and frozen storage
Transfusion2017Vol. 57(4), pp. 1019–1030
Citations Over TimeTop 10% of 2017 papers
Angelo D’Alessandro, A. Gray, Zbigniew M. Szczepiorkowski, Kirk C. Hansen, Louise Herschel, Larry J. Dumont
Abstract
Rejuvenation reversed over one-half of the metabolic biochemical compounds evaluated compared with Day 42 values, and the compounds were stable through frozen storage and preparation for transfusion. Rejuvenation promoted significant metabolic reprogramming, including the reactivation of energy-generating and antioxidant pathways (the pentose phosphate pathway and glutathione homeostasis), salvage reactions, cofactor reservoirs, and membrane lipid recycling.
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