Red blood cell specifications for patients with hemoglobinopathies: a systematic review and guideline
Transfusion2018Vol. 58(6), pp. 1555–1566
Citations Over TimeTop 10% of 2018 papers
Veerle Compernolle, Stella T. Chou, Susano Tanael, William Savage, Jo Howard, Cassandra D. Josephson, Isaac Odame, Christopher J. Hogan, Gregory A. Denomme, Nadine Shehata
Abstract
The panel recommends that ABO D CcEe K-matched RBCs are selected for individuals with SCD and β-thalassemia, even in the absence of alloantibodies, to reduce the risk of alloimmunization. In patients with SCD and β-thalassemia who have developed clinically significant alloantibodies, selection of RBCs antigen negative to the alloantibody is recommended, if feasible. In these patients, selection of more extended phenotype-matched RBCs will likely reduce the risk of further alloimmunization. However, given the limited availability of extended phenotype-matched units, attention should be given to ensure that a delay in transfusion does not adversely affect patient care.
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