Pre‐clinical development of a cryopreservable megakaryocytic cell product capable of sustained platelet production in mice
Transfusion2019Vol. 59(12), pp. 3698–3713
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Ami B. Patel, Cara Clementelli, Danuta Jarocha, Gohar Mosoyan, Cindy Else, Manisha Kintali, Helen Fong, Jay Tong, Ronald Gordon, Virginia Gillespie, Alla Keyzner, Mortimer Poncz, Ronald Hoffman, Camelia Iancu‐Rubin
Abstract
This is a proof-of-principle study demonstrating the creation of a cryopreservable megakaryocytic cell product which releases functional PLTs in vivo. Clinical development of such a product is currently being pursued for the treatment of thrombocytopenia in patients with hematological malignancies.
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