Liver transplantation versus liver resection for colorectal liver metastasis: a survival benefit analysis in patients stratified according to tumor burden score

Citations Over TimeTop 10% of 2021 papers

Abstract

Liver transplantation (LT) for colorectal liver metastasis (CRLM) may provide excellent survival rates in patients with unresectable disease. High tumor load is a risk factor for recurrence and low overall survival (OS) after liver resection (LR). We tested the hypothesis that LT could offer better survival than LR in patients with high tumor load. LR performed at Padua University Hospital for CRLM was compared with LT for unresectable CRLM performed both at Oslo and Padua. High tumor load was defined as tumor burden score (TBS) ≥ 9, and inclusion criteria were as in the SECA-I transplant study. 184 patients were eligible: 128 LRs and 56 LTs. 5-year OS after LR and LT was 40.5% and 54.7% (P = 0.102). In the high TBS cohort, 5-year OS after LR and LT was 22.7% and 52.2% (P = 0.055). In patients with Oslo score ≤ 2 and TBS ≥ 9 (13 LR; 24 LT) the 5-year OS after LR and LT was 14.6% and 69.1% (P = 0.002). The corresponding disease-free survival (DFS) was 0% and 22.9% (P = 0.005). Selected CRLM patients with low Oslo score and high TBS could benefit from LT with survival outcomes that are far better than what is achieved by LR.

Related Papers

• → Correlation between the expression of the BAG-1 gene and clinicopathologic factors in colorectal cancer(2011)4 cited
• → TC22, a Novel Colorectal Cancer Biomarker Remains Continuously Suppressed Upon Repeated Mesalamine Exposure to Colorectal Cancer Cells(2011)
• δ-catenin Expression Correlates with Cell Proliferation in Colorectal Cancer(2013)
• Expression of PTTG and its significance in colorectal cancer(2008)
• → Expression of Galecitn-9 in colorectal cancer and its clinical significance(2023)