Intravenous lipid emulsion therapy in three cases of canine naproxen overdose
Journal of Veterinary Emergency and Critical Care2015Vol. 25(5), pp. 672–678
Citations Over TimeTop 10% of 2015 papers
Abstract
Naproxen is a nonsteroidal anti-inflammatory drug with a long half-life and narrow margin of safety in dogs. Ingestion of > 5 mg/kg has been associated with adverse gastrointestinal effects, including ulceration. At doses > 10-25 mg/kg, acute kidney failure has been reported, and at doses > 50 mg/kg, neurologic abnormalities occur. This is the first reported use of IVLE for treatment of naproxen overdose with documented decrease in serum toxin concentrations shortly after administration. No long-standing gastrointestinal, renal, or neurologic effects occurred in these dogs.
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