Clinical neurocardiology defining the value of neuroscience‐based cardiovascular therapeutics
The Journal of Physiology2016Vol. 594(14), pp. 3911–3954
Citations Over TimeTop 1% of 2016 papers
Kalyanam Shivkumar, Olujimi A. Ajijola, Inder S. Anand, J. Andrew Armour, Peng‐Sheng Chen, Murray Esler, Gaetano Maria De Ferrari, Michael C. Fishbein, Jeffrey J. Goldberger, Ronald M. Harper, Michael J. Joyner, Sahib S. Khalsa, Rajesh Kumar, Richard D. Lane, Aman Mahajan, Sunny S. Po, Peter J. Schwartz, Virend K. Somers, Miguel Valderrábano, Marmar Vaseghi, Douglas P. Zipes
Abstract
The autonomic nervous system regulates all aspects of normal cardiac function, and is recognized to play a critical role in the pathophysiology of many cardiovascular diseases. As such, the value of neuroscience-based cardiovascular therapeutics is increasingly evident. This White Paper reviews the current state of understanding of human cardiac neuroanatomy, neurophysiology, pathophysiology in specific disease conditions, autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression of cardiovascular diseases.
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