Effects of uniform extracellular DC electric fields on excitability in rat hippocampal slices in vitro
The Journal of Physiology2004Vol. 557(1), pp. 175–190
Citations Over TimeTop 14% of 2004 papers
Marom Bikson, Masashi Inoue, Hiroki Akiyama, Jackie K. Deans, J. E. D. Fox, Hiroyoshi Miyakawa, John G. R. Jefferys
Abstract
The effects of uniform steady state (DC) extracellular electric fields on neuronal excitability were characterized in rat hippocampal slices using field, intracellular and voltage-sensitive dye recordings. Small electric fields (1 s) changes in neuronal excitability. Electric fields perpendicular to the apical-dendritic axis did not induce somatic polarization, but did modulate orthodromic responses, indicating an effect on afferents. These results demonstrate that DC fields can modulate neuronal excitability in a time-dependent manner, with no clear threshold, as a result of interactions between neuronal compartments, the non-linear properties of the cell membrane, and effects on afferents.
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