Neutrophils preferentially phagocytose elongated particles—An opportunity for selective targeting in acute inflammatory diseases
Citations Over TimeTop 10% of 2020 papers
Abstract
Polymeric particles have recently been used to modulate the behavior of immune cells in the treatment of various inflammatory conditions. However, there is little understanding of how physical particle parameters affect their specific interaction with different leukocyte subtypes. While particle shape is known to be a crucial factor in their phagocytosis by macrophages, where elongated particles are reported to experience reduced uptake, it remains unclear how shape influences phagocytosis by circulating phagocytes, including neutrophils that are the most abundant leukocyte in human blood. In this study, we investigated the phagocytosis of rod-shaped polymeric particles by human neutrophils relative to other leukocytes. In contrast to macrophages and other mononuclear phagocytes, neutrophils were found to exhibit increased internalization of rods in ex vivo and in vivo experimentation. This result suggests that alteration of particle shape can be used to selectively target neutrophils in inflammatory pathologies where these cells play a substantial role.
Related Papers
- → The phagocytic role of macrophage following myocardial infarction(2023)12 cited
- → Role of carboxyl tail of the rat angiotensin II type 1A receptor in agonist-induced internalization of the receptor(1994)32 cited
- → Consequences of internalization and phagocytosis of Listeria during an infectious process(2003)2 cited
- → Function of Macrophage Prostaglandins in the Process of Phagocytosis(1980)14 cited
- → The Internalization and Therapeutic Activity of Antibody Drug Conjugates(2023)