Design and tuning of ionic liquid–based HNO donor through intramolecular hydrogen bond for efficient inhibition of tumor growth

Citations Over Time

Abstract

Developing ionic liquid (IL) drugs broaden new horizons in pharmaceuticals. The tunable nature endows ILs with capacity to delivery active ingredients. However, the tunability is limited to screen ionic components, and none realizes the kinetic tuning of drug release, which is a key challenge in the design of IL drugs. Here, a series of ILs are developed using biocompatible ionic components, which realizes absorption of gaseous NO to yield IL-NONOates. These IL-NONOates serve as HNO donors to release active ingredient. The release kinetics can be tuned through configuring the geometric construction of ILs (release half-lives, 4.2 to 1061 min). Mechanism research indicates that the tunability depends on the strength of intramolecular hydrogen bond. Furthermore, the IL-based HNO donors exert pharmacological potential to inhibit tumor progression by regulating intratumoral redox state. Coupled with biosafety, these IL-based HNO donors with facile preparation and tunable functionalization can be promising candidates for pharmaceutical application.

Related Papers

• → Identification of intramolecular hydrogen bonds as the origin of malfunctioning of multitopic receptors(2012)95 cited
• → Intramolecular Hydrogen Bond Interaction in Selected Diols(2003)17 cited
• → Infrared spectroscopic study of C₇ intramolecular hydrogen bonds in peptides(1983)27 cited
• → Intramolecular hydrogen bonding and intermolecular association of amino alcohols(1986)14 cited
• → Crystal Structure and Intramolecular Hydrogen Bonding of a Substituted Diaminoquinoxaline(2009)