Deformable microparticles for shuttling nanoparticles to the vascular wall

Citations Over TimeTop 10% of 2021 papers

Abstract

Vascular-targeted drug carriers must localize to the wall (i.e., marginate) and adhere to a diseased endothelium to achieve clinical utility. The particle size has been reported as a critical physical property prescribing particle margination in vitro and in vivo blood flows. Different transport process steps yield conflicting requirements-microparticles are optimal for margination, but nanoparticles are better for intracellular or tissue delivery. Here, we evaluate deformable hydrogel microparticles as carriers for transporting nanoparticles to a diseased vascular wall. Depending on microparticle modulus, nanoparticle-loaded poly(ethylene glycol)-based hydrogel microparticles delivered significantly more 50-nm nanoparticles to the vessel wall than freely injected nanoparticles alone, resulting in >3000% delivery increase. This work demonstrates the benefit of optimizing microparticles' efficient margination to enhance nanocarriers' transport to the vascular wall.

Related Papers

• → Multifunctional nanocarriers☆(2006)1,242 cited
• → Delivering more for less: nanosized, minimal-carrier and pharmacoactive drug delivery systems(2021)87 cited
• → Endosomes as a route for drug delivery in the real world(2004)32 cited
• → Nanoparticle-mediated Drug Delivery Systems (DDS) in the Central Nervous System(2016)6 cited
• Collagen Microparticles in Drug Delivery(2010)