Pluripotency factors regulate the onset of Hox cluster activation in the early embryo
Citations Over TimeTop 18% of 2022 papers
Abstract
Pluripotent cells are a transient population of the mammalian embryo dependent on transcription factors, such as OCT4 and NANOG, which maintain pluripotency while suppressing lineage specification. However, these factors are also expressed during early phases of differentiation, and their role in the transition from pluripotency to lineage specification is largely unknown. We found that pluripotency factors play a dual role in regulating key lineage specifiers, initially repressing their expression and later being required for their proper activation. We show that Oct4 is necessary for activation of HoxB genes during differentiation of embryonic stem cells and in the embryo. In addition, we show that the HoxB cluster is coordinately regulated by OCT4 binding sites located at the 3' end of the cluster. Our results show that core pluripotency factors are not limited to maintaining the precommitted epiblast but are also necessary for the proper deployment of subsequent developmental programs.
Related Papers
- → 40 years of the homeobox: mechanisms of Hox spatial-temporal collinearity in vertebrates(2024)16 cited
- → fushi tarazu: A Hox gene changes its role(2002)24 cited
- → Regulation of Hox gene expression during anteroposterior patterning involves collinear Hox-Hox interactions(2017)
- Hox Gene Clusters of Early Vertebrates： Do They Serve as Reliable Markers for Genome Evolution？(2011)
- → ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ(2024)