Resolution of Lung Inflammation by CD44
Science2002Vol. 296(5565), pp. 155–158
Citations Over TimeTop 1% of 2002 papers
Priit Teder, R. William Vandivier, Dianhua Jiang, Jiurong Liang, Lauren Cohn, Ellen Puré, Peter M. Henson, Paul W. Noble
Abstract
Successful repair after tissue injury and inflammation requires resolution of the inflammatory response and removal of extracellular matrix breakdown products. We have examined whether the cell-surface adhesion molecule and hyaluronan receptor CD44 plays a role in resolving lung inflammation. CD44-deficient mice succumb to unremitting inflammation following noninfectious lung injury, characterized by impaired clearance of apoptotic neutrophils, persistent accumulation of hyaluronan fragments at the site of tissue injury, and impaired activation of transforming growth factor-beta1. This phenotype was partially reversed by reconstitution with CD44+ cells, thus demonstrating a critical role for this receptor in resolving lung inflammation.
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