Semaphorin 3E and Plexin-D1 Control Vascular Pattern Independently of Neuropilins

Citations Over TimeTop 1% of 2004 papers

Abstract

The development of a patterned vasculature is essential for normal organogenesis. We found that signaling by semaphorin 3E (Sema3E) and its receptor plexin-D1 controls endothelial cell positioning and the patterning of the developing vasculature in the mouse. Sema3E is highly expressed in developing somites, where it acts as a repulsive cue for plexin-D1-expressing endothelial cells of adjacent intersomitic vessels. Sema3E-plexin-D1 signaling did not require neuropilins, which were previously presumed to be obligate Sema3 coreceptors. Moreover, genetic ablation of Sema3E or plexin-D1 but not neuropilin-mediated Sema3 signaling disrupted vascular patterning. These findings reveal an unexpected semaphorin signaling pathway and define a mechanism for controlling vascular patterning.

Related Papers

• → Neuropilin-2 Is a Receptor for Semaphorin IV Insight into the Structural Basis of Receptor Function and Specificity(1998)354 cited
• → Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A(2000)247 cited
• → Discovery of semaphorin receptors, neuropilin and plexin, and their functions in neural development(2004)174 cited
• → Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex(2021)51 cited
• → Structure of Functional Neuropilin-Centred Class 3 Semaphorin and VEGF Receptors(2017)2 cited