Genome of the Host-Cell Transforming Parasite Theileria annulata Compared with T. parva
Science2005Vol. 309(5731), pp. 131–133
Citations Over TimeTop 1% of 2005 papers
Arnab Pain, Hubert Renauld, Matthew Berriman, Lee Murphy, Corin Yeats, William Weir, Arnaud Kerhornou, Martin Aslett, Richard P. Bishop, Christiane Bouchier, Madeleine Cochet, Richard Coulson, Ann Cronin, Etienne P. de Villiers, Audrey Fraser, Nigel Fosker, Malcolm J. Gardner, Arlette Goble, Sam Griffiths‐Jones, David Harris, Frank Katzer, Natasha Larke, Angela Lord, Pascal Mäser, Sue McKellar, Paul Mooney, Fraser Morton, Vishvanath Nene, Susan O’Neil, Claire Price, Michael A. Quail, Ester Rabbinowitsch, Neil D. Rawlings, Simon Rutter, David Saunders, Kathy Seeger, Trushar Shah, Robert Squares, Steven Squares, Adrian R. Tivey, A.R. Walker, John R. Woodward, D. Dobbelaere, Gordon Langsley, Marie-Adele Rajandream, Declan J. McKeever, Brian Shiels, Andrew Tait, Bart Barrell, Neil Hall
Abstract
Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.
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