Increase in Activity During Calorie Restriction Requires Sirt1
Science2005Vol. 310(5754), pp. 1641–1641
Citations Over TimeTop 10% of 2005 papers
Abstract
Sir2 (silent information regulator 2) is a nicotinamide adenine dinucleotide-dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.
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