Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension
Science2007Vol. 315(5816), pp. 1243–1249
Citations Over TimeTop 1% of 2007 papers
Maurice A. Curtis, Monica Kam, Ulf Nannmark, Michelle F. Anderson, Mathilda Zetterström Axell, Carsten Wikkelsø, S. Holtås, Willeke van Roon‐Mom, Thomas Björk‐Eriksson, Claes Nordborg, Jonas Frisén, Michael Dragunow, Richard L. M. Faull, Peter S. Eriksson
Abstract
The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2'-deoxyuridine and become mature neurons in the OB.
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