Requirement of bic/microRNA-155 for Normal Immune Function

Citations Over TimeTop 1% of 2007 papers

Abstract

MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155-deficient CD4+ T cells identified a wide spectrum of microRNA-155-regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system.

Related Papers

• → Novel regulation and functional interaction of polycistronic miRNAs(2015)61 cited
• → Expression levels of microRNAs are not associated with their regulatory activities(2011)21 cited
• → Under-expression of microRNA-146a and 21 and their association with Crohn’s disease(2020)8 cited
• → Προσδιορισμός κυκλοφορούντων oncomiRs και angiomiRs στο αίμα ασθενών με καρκίνο και διερεύνηση της διαγνωστικής, προγνωστικής και προβλεπτικής τους ικανότητας(2016)
• → MicroRNA-155 (miRNA-155); miRNA-363* ; miRNA-206; miRNA-494; miRNA-155; miRNA-184; miRNA-542-3p; miRNA-9*(2009)