A Common Allele on Chromosome 9 Associated with Coronary Heart Disease
Science2007Vol. 316(5830), pp. 1488–1491
Citations Over TimeTop 1% of 2007 papers
Ruth McPherson, Alexander Pertsemlidis, Nihan Kavaslar, Alexandre F.R. Stewart, Robert Roberts, David R. Cox, David A. Hinds, L Pennacchio, Anne Tybjærg‐Hansen, Aaron R. Folsom, Eric Boerwinkle, Helen H. Hobbs, Jonathan C. Cohen
Abstract
Coronary heart disease (CHD) is a major cause of death in Western countries. We used genome-wide association scanning to identify a 58-kilobase interval on chromosome 9p21 that was consistently associated with CHD in six independent samples (more than 23,000 participants) from four Caucasian populations. This interval, which is located near the CDKN2A and CDKN2B genes, contains no annotated genes and is not associated with established CHD risk factors such as plasma lipoproteins, hypertension, or diabetes. Homozygotes for the risk allele make up 20 to 25% of Caucasians and have a approximately 30 to 40% increased risk of CHD.
Related Papers
- → CDKN2A/B Alterations Impair Prognosis in Adult BCR-ABL1 –Positive Acute Lymphoblastic Leukemia Patients(2011)73 cited
- → Biallelic loss ofCDKN2Ais associated with poor response to treatment in pediatric acute lymphoblastic leukemia(2016)49 cited
- → Expression Analysis of Genes Involved in the RB/E2F Pathway in Astrocytic Tumors(2015)17 cited
- → Abstract 311: Loss of the tumor suppressor genes CDKN2A/ARF impairs prognosis in adult BCR-ABL1 positive acute lymphoblastic leukemia (ALL)(2011)1 cited
- → 520P Copy number variation spectrum analysis of primary glioblastoma(2023)