Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation
Citations Over TimeTop 1% of 2010 papers
Abstract
A major obstacle for the discovery of psychoactive drugs is the inability to predict how small molecules will alter complex behaviors. We report the development and application of a high-throughput, quantitative screen for drugs that alter the behavior of larval zebrafish. We found that the multidimensional nature of observed phenotypes enabled the hierarchical clustering of molecules according to shared behaviors. Behavioral profiling revealed conserved functions of psychotropic molecules and predicted the mechanisms of action of poorly characterized compounds. In addition, behavioral profiling implicated new factors such as ether-a-go-go-related gene (ERG) potassium channels and immunomodulators in the control of rest and locomotor activity. These results demonstrate the power of high-throughput behavioral profiling in zebrafish to discover and characterize psychotropic drugs and to dissect the pharmacology of complex behaviors.
Related Papers
- → Cold exposure down-regulates zebrafish pigmentation(2011)16 cited
- Establishment of Multi-Site Infection Model in Zebrafish Larvae for Studying Staphylococcus aureus Infectious Disease(2012)
- → Μελέτη των μηχανισμών εκδήλωσης συγγενών καρδιοπαθειών με την χρήση του zebrafish ως πειραματικό μοντέλο(2016)
- → Διερεύνηση μηχανισμών ανάπτυξης καρδιαγγειακών νόσων χρησιμοποιώντας το πειραματόζωο Danio rerio (zebrafish)(2020)
- → Μελέτη μηχανισμών καρδιοπαθειών χρησιμοποιώντας το Zebrafish ως πειραματικό μοντέλο(2020)