Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
Citations Over TimeTop 1% of 1997 papers
Abstract
Angiogenesis is thought to depend on a precise balance of positive and negative regulation. Angiopoietin-1 (Ang1) is an angiogenic factor that signals through the endothelial cell-specific Tie2 receptor tyrosine kinase. Like vascular endothelial growth factor, Ang1 is essential for normal vascular development in the mouse. An Ang1 relative, termed angiopoietin-2 (Ang2), was identified by homology screening and shown to be a naturally occurring antagonist for Ang1 and Tie2. Transgenic overexpression of Ang2 disrupts blood vessel formation in the mouse embryo. In adult mice and humans, Ang2 is expressed only at sites of vascular remodeling. Natural antagonists for vertebrate receptor tyrosine kinases are atypical; thus, the discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system.
Related Papers
- → Angiopoietin-2 Is Required for Postnatal Angiogenesis and Lymphatic Patterning, and Only the Latter Role Is Rescued by Angiopoietin-1(2002)1,010 cited
- → The role of the Angiopoietins in vascular morphogenesis(2009)393 cited
- → Angiopoietin-2/Tie2 signaling involved in TNF-a induced peritoneal angiogenesis(2012)10 cited
- → 27 Expression of Angiopoietin-1, Angiopoietin-2, and Tie2 in Normal Ovary with Corpus Luteum and in Ovarian Carcinoma(2005)
- Role of angiopoietin-tie2 system in ocular vascular diseases = 안구 혈관 질환에서 Angiopoietin-Tie2 신호전달체계의 역할(2018)