Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria–specific CD4 + T cells
Citations Over TimeTop 1% of 2015 papers
Abstract
Inflammatory CD4(+) T cell responses to self or commensal bacteria underlie the pathogenesis of autoimmunity and inflammatory bowel disease (IBD), respectively. Although selection of self-specific T cells in the thymus limits responses to mammalian tissue antigens, the mechanisms that control selection of commensal bacteria-specific T cells remain poorly understood. Here, we demonstrate that group 3 innate lymphoid cell (ILC3)-intrinsic expression of major histocompatibility complex class II (MHCII) is regulated similarly to thymic epithelial cells and that MHCII(+) ILC3s directly induce cell death of activated commensal bacteria-specific T cells. Further, MHCII on colonic ILC3s was reduced in pediatric IBD patients. Collectively, these results define a selection pathway for commensal bacteria-specific CD4(+) T cells in the intestine and suggest that this process is dysregulated in human IBD.
Related Papers
- → Function of innate lymphoid cells in the immune-related disorders(2019)35 cited
- → Innate Lymphoid Cells and Intestinal Inflammatory Disorders(2022)25 cited
- → Roles of type 2 innate lymphoid cells in the pathogenesis of bronchial asthma(2016)
- → [Type 2 innate lymphoid cells and chronic rhinosinusitis].(2016)
- → Updates on type 2 innate lymphoid cells and allergic diseases(2017)