Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

Citations Over TimeTop 1% of 2017 papers

Abstract

Dendritic cells (DCs) and monocytes play a central role in pathogen sensing, phagocytosis, and antigen presentation and consist of multiple specialized subtypes. However, their identities and interrelationships are not fully understood. Using unbiased single-cell RNA sequencing (RNA-seq) of ~2400 cells, we identified six human DCs and four monocyte subtypes in human blood. Our study reveals a new DC subset that shares properties with plasmacytoid DCs (pDCs) but potently activates T cells, thus redefining pDCs; a new subdivision within the CD1C+ subset of DCs; the relationship between blastic plasmacytoid DC neoplasia cells and healthy DCs; and circulating progenitor of conventional DCs (cDCs). Our revised taxonomy will enable more accurate functional and developmental analyses as well as immune monitoring in health and disease.

Related Papers

• → Exercise paradoxically modulates oxidized low density lipoproteininduced adhesion molecules expression and trans-endothelial migration of monocyte in men(2005)16 cited
• → Circulating Committed and Pluripotent Haemopoietic Progenitor Cells, in Infants(1986)17 cited
• → The helper function of monocytes from aged humans in lymphocyte activation by mitogens.(1985)
• The Effects of CCR5-Binding Peptide on Chemotaxis of Monocyte(2006)
• → Correlation between Entothelial Microparticle Binding to Monocytes and Monocyte Nitric Oxide Production in Prothrombotic and Inflammatory Disorders.(2005)