Stellate cells drive maturation of the entorhinal-hippocampal circuit
Citations Over TimeTop 10% of 2017 papers
Abstract
The neural representation of space relies on a network of entorhinal-hippocampal cell types with firing patterns tuned to different abstract features of the environment. To determine how this network is set up during early postnatal development, we monitored markers of structural maturation in developing mice, both in naïve animals and after temporally restricted pharmacogenetic silencing of specific cell populations. We found that entorhinal stellate cells provide an activity-dependent instructive signal that drives maturation sequentially and unidirectionally through the intrinsic circuits of the entorhinal-hippocampal network. The findings raise the possibility that a small number of autonomously developing neuronal populations operate as intrinsic drivers of maturation across widespread regions of the cortex.
Related Papers
- → What is the Source of the EEG?(2009)195 cited
- → Difference in axon diameter and myelin thickness between excitatory and inhibitory callosally projecting axons in mice(2022)20 cited
- → Degree of synchronization modulated by inhibitory neurons in clustered excitatory-inhibitory recurrent networks(2018)7 cited
- → Effects of Inhibitory Signal on Criticality in Excitatory-Inhibitory Networks*(2019)2 cited
- [Interaction of excitatory and inhibitory processes in the proposed inhibitory interneurons of the hippocampus].(1980)