Evolutionary History of the Closely Related Group 2 Coronaviruses: Porcine Hemagglutinating Encephalomyelitis Virus, Bovine Coronavirus, and Human Coronavirus OC43
Journal of Virology2006Vol. 80(14), pp. 7270–7274
Citations Over TimeTop 10% of 2006 papers
Leen Vijgen, Els Keyaerts, Philippe Lemey, Piet Maes, Kristien Van Reeth, Hans Nauwynck, Maurice Pensaert, Marc Van Ranst
Abstract
The close genetic and antigenic relatedness among the group 2 coronaviruses human coronavirus OC43 (HCoV-OC43), bovine coronavirus (BCoV), and porcine hemagglutinating encephalomyelitis virus (PHEV) suggests that these three viruses with different host specificities diverged fairly recently. In this study, we determined the complete genomic sequence of PHEV (strain PHEV-VW572), revealing the presence of a truncated group 2-specific ns2 gene in PHEV in comparison to other group 2 coronaviruses. Using a relaxed molecular clock approach, we reconstructed the evolutionary relationships between PHEV, BCoV, and HCoV-OC43 in real-time units, which indicated relatively recent common ancestors for these species-specific coronaviruses.
Related Papers
- → Coronavirus infection in mink (Mustela vision). Serological evidence of infection with a coronavirus related to transmissible gastroenteritis virus and porcine epidemic diarrhea virus(1992)66 cited
- → Antigenic relationship of the feline infectious peritonitis virus to coronaviruses of other species(1978)152 cited
- → An immunoelectron microscopic and immunofluorescent study on the antigenic relationship between the coronavirus-like agent, CV 777, and several coronaviruses(1981)75 cited
- → Assembly of Coronaviridae(1984)12 cited
- SARS-Related coronavirus and its relationship with animal coronaviruses(2004)