WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis
Annals of the Rheumatic Diseases2016Vol. 76(1), pp. 218–226
Citations Over TimeTop 1% of 2016 papers
Giovanna Nalesso, B.L. Thomas, J. Sherwood, Jing Yu, Olga Addimanda, S. Eldridge, Anne‐Sophie Thorup, Leslie Dale, Georg Schett, Jochen Zwerina, Noha Eltawil, Costantino Pitzalis, Francesco Dell’Accio
Abstract
In osteoarthritis, WNT16 maintains a balanced canonical WNT signalling and prevents detrimental excessive activation, thereby supporting the homeostasis of progenitor cells.
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