Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren's syndrome
Annals of the Rheumatic Diseases2018Vol. 78(2), pp. 249–260
Citations Over TimeTop 10% of 2018 papers
Saba Nayar, Joana Campos, Charlotte G. Smith, Valentina Iannizzotto, David H. Gardner, Serena Colafrancesco, Elena Pipi, Florian Kollert, Kelly J. Hunter, Charlotte Brewer, Christopher D. Buckley, Simon Bowman, Roberta Priori, Guido Valesini, Maria Juárez, William A. Fahy, Benjamin A. Fisher, Andrew Payne, Rodger A. Allen, Francesca Barone
Abstract
These data demonstrate activation of PI3Kδ pathway within the glands of patients with pSS and its contribution to disease pathogenesis in a model of disease, supporting the exploration of the therapeutic potential of PI3Kδ pathway inhibition in this condition.
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