Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data
BMJ2014Vol. 349(jul10 6), pp. g4164–g4164
Citations Over TimeTop 1% of 2014 papers
Michael V. Holmes, Caroline Dale, Luisa Zuccolo, Richard J. Silverwood, Yanfei Guo, Z. Ye, David Prieto‐Merino, Abbas Dehghan, Stella Trompet, Andrew Wong, Alana Cavadino, Dagmar Drogan, Sandosh Padmanabhan, Simon Li, Ajay Yesupriya, Maarten Leusink, Johan Sundström, Jaroslav A. Hubáček, Hynek Pikhart, Daniel I. Swerdlow, Andrie G. Panayiotou, S. A. Borinskaya, Chris Finan, Sonia Shah, Karoline Kuchenbaecker, Tina Shah, Jorgen Engmann, Lasse Folkersen, Per Eriksson, Fulvio Ricceri, Olle Melander, Carlotta Sacerdote, Dale M. Gamble, Sruti Rayaprolu, Owen A. Ross, S. McLachlan, Olga Vikhireva, Ivonne Sluijs, R.A. Scott, Věra Adámková, Leon Flicker, F. M. van Bockxmeer, Chris Power, Pedro Marques‐Vidal, T W Meade, Michael Marmot, José M. Ferro, S. Paulos-Pinheiro, Steve E. Humphries, Philippa J. Talmud, Irene Mateo Leach, Niek Verweij, Allan Linneberg, Tea Skaaby, Pieter A. Doevendans, Maarten J. Cramer, Pim van der Harst, Olaf H. Klungel, Nicole F. Dowling, Anna F. Dominiczak, Meena Kumari, Andrew Nicolaides, Cornelia Weikert, Heiner Boeing, Shah Ebrahim, Tom R. Gaunt, Jackie F. Price, L. Lannfelt, Anne Peasey, Růžena Kubínová, A. Pajak, Sofia Malyutina, M. I. Voevoda, Algirdas Tamošiūnas, Anke H. Maitland‐van der Zee, Paul E. Norman, Graeme J. Hankey, Michael Bergmann, Amy Hofman, Oscar H. Franco, J. Cooper, Jutta Palmen, Wilko Spiering, Pim A. de Jong, Diana Kuh, Rebecca Hardy, André G. Uitterlinden, M. Arfan Ikram, Ian Ford, Elina Hyppönen, Osvaldo P. Almeida, Nicholas J. Wareham, K.-T. Khaw, Anders Hamsten, Lise Lotte N. Husemoen, Anne Tjønneland, Janne Schurmann Tolstrup, Eric B. Rimm, Joline W. J. Beulens, W. M. Monique Verschuren, N. Charlotte Onland‐Moret, Marten H. Hofker, S. Goya Wannamethee, Peter H. Whincup, Richard Morris, Astrid M. Vicente, Hugh Watkins, Martin Farrall, J. Wouter Jukema, James F. Meschia, L. Adrienne Cupples, Stephen J. Sharp, M. Fornage, Charles Kooperberg, Andrea Z. LaCroix, Jiyan Dai, Matthew B. Lanktree, David S. Siscovick, Eric Jorgenson, Bonnie Spring, Josef Coresh, Leslie A. Lange, Sarah G. Buxbaum, Pamela J. Schreiner, R. Curtis Ellison, Michael Y. Tsai, Sanjay R. Patel, Susan Redline, Andrew D. Johnson, Ron C. Hoogeveen, H. Hakonarson, Jerome I. Rotter, Eric Boerwinkle, Paul I. W. de Bakker, Mika Kivimäki, Folkert W. Asselbergs, Naveed Sattar, Debbie A. Lawlor, John C. Whittaker, George Davey Smith, K. Mukamal, Bruce M. Psaty, James Wilson, Leslie A. Lange, Ajna Hamidovic, Aroon D. Hingorani, Børge G. Nordestgaard, Martin Bobák, David A. Leon, Claudia Langenberg, Tom Palmer, Alex P. Reiner, Brendan J. Keating, Frank Dudbridge, J. P. Casas
Abstract
Individuals with a genetic variant associated with non-drinking and lower alcohol consumption had a more favourable cardiovascular profile and a reduced risk of coronary heart disease than those without the genetic variant. This suggests that reduction of alcohol consumption, even for light to moderate drinkers, is beneficial for cardiovascular health.
Related Papers
- → Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects(2015)1,715 cited
- → Re: “Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects”(2015)1,009 cited
- → Serum Triglycerides and Atherosclerotic Cardiovascular Disease: Insights from Clinical and Genetic Studies(2018)52 cited
- → Mendelian Randomization: How Genetics Is Pushing the Boundaries of Epidemiology to Identify New Causes of Heart Disease(2012)22 cited
- → Genetic Evidence of Causal Effect between C1q/TNF-Related Protein-1 and Atherosclerosis: a Bidirectional and Multivariate Mendelian Randomization Study(2024)