NOD2 (CARD15) mutations in Crohn’s disease are associated with diminished mucosal α-defensin expression
Gut2004Vol. 53(11), pp. 1658–1664
Citations Over TimeTop 1% of 2004 papers
Jan Wehkamp, Jürgen Harder, Michael Weichenthal, Matthias Schwab, Elke Schäffeler, Miriam Schlee, K Herrlinger, Andreas Stallmach, Florian Noack, Péter Fritz, J.‐M. Schröder, Charles Bevins, Klaus Fellermann, Eduard F. Stange
Abstract
As alpha defensins are important in the mucosal antibacterial barrier, their diminished expression may explain, in part, the bacterial induced mucosal inflammation and ileal involvement of Crohn's disease, especially in the case of NOD2 mutations.
Related Papers
- → Defensins and inflammation: The role of defensins in inflammatory bowel disease(2009)176 cited
- → Activation of NOD2-mediated intestinal pathway in a pediatric population with Crohnʼs disease(2009)54 cited
- → Muramyl dipeptide responsive pathways in Crohn’s disease: from NOD2 and beyond(2012)34 cited
- → The evolving management of postoperative Crohn’s disease(2012)27 cited
- → W1254 The Three Common CARD15/NOD2 Polymorphisms Associated With Crohn's Disease are Rare or Absent in a UK South Asian Crohn's Disease Population(2010)