Mechanisms regulating cytochrome c release in pancreatic mitochondria
Gut2008Vol. 58(3), pp. 431–442
Citations Over TimeTop 10% of 2008 papers
Irina Odinokova, K F Sung, Olga A. Mareninova, Kay‐Geert Hermann, Yu. V. Evtodienko, Alexander Y. Andreyev, Ilya Gukovsky, Anna S. Gukovskaya
Abstract
These data implicate ROS as a key mediator of CCK-induced apoptotic responses. The results indicate a major role for mitochondria in the effects of Ca(2+ )and ROS on acinar cell death. They suggest that the extent of apoptosis in pancreatitis is regulated by the interplay between ROS, Delta Psi m and Ca(2+). Stabilising mitochondria against loss of Delta Psi m may represent a strategy to mitigate the severity of pancreatitis.
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